Hoekstra A
Centre for Biomedical Technology, Faculty of Medicine, University of Groningen, The Netherlands.
Int J Artif Organs. 1994 Mar;17(3):151-4.
Various totally implantable drug delivery systems from single access ports to micropumps are now available for administration of repeated boluses, and continuous or programmable infusions. In this respect, emphasis is given to a relatively cheap, totally implantable system for self-administering intraspinal opiates in the treatment of cancer pain. The SECOR pump system, developed by Cordis, consists of a dual pump with refill port and safety valve. The volume of the pliable reservoir is 12 ml and refill is accomplished with a 25-G needle. The bolus delivered with each transcutaneous activation of the pumps is 0.1 ml. Clinical results demonstrated that this patient-controlled drug delivery system is safe and provides excellent pain relief associated with terminal cancer. A possible advantage of this drug delivery system over continuous infusion pumps is that patients can elect to have the morphine delivered only when they feel pain. Thus pain relief would be maximized and tolerance build-up would be minimized.
现在有各种完全植入式药物输送系统，从单通道端口到微型泵，可用于重复推注给药、持续输注或可编程输注。在这方面，重点介绍一种相对便宜的完全植入式系统，用于在癌症疼痛治疗中自行注射脊髓内阿片类药物。Cordis公司开发的SECOR泵系统由一个带有重新填充端口和安全阀的双泵组成。柔软储液器的容积为12毫升，用25G针头进行重新填充。每次经皮激活泵输送的推注量为0.1毫升。临床结果表明，这种患者自控药物输送系统是安全的，并且能为晚期癌症患者提供出色的疼痛缓解。与持续输注泵相比，这种药物输送系统的一个可能优势是患者可以选择仅在感到疼痛时才注射吗啡。因此，疼痛缓解将最大化，耐受性的形成将最小化。
