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重复DNA在黑腹果蝇染色体重排过程中的重组连接中可能发挥的作用。

A possible role of repetitious DNA in recombinatory joining during chromosome rearrangement in Drosophila melanogaster.

作者信息

Lee C S

出版信息

Genetics. 1975 Mar;79(3):467-70. doi: 10.1093/genetics/79.3.467.

Abstract

It is postulated that certain repetitious DNA components play a role in the recombination processes during chromoxome reappangements. When the distribution of silver grain densities after the in situ hybridization of repetitious DNA (RUDKIN and TARTOF 1973) and the distribution of chromosome breaks due to X-irradiation (KAUFMANN 1946) are compared, a strong correlation is found for the euchromatic portion of the D. melanogaster salivary X chromosome. These observations justify the postulate above that certain repetitious DNA provides homologous regions in the DNA of broken chromosome ends necessary for proper recombinatory joining.

摘要

据推测,某些重复的DNA成分在染色体重新排列过程中的重组过程中发挥作用。当比较重复DNA原位杂交后银粒密度的分布(RUDKIN和TARTOF,1973年)与X射线照射导致的染色体断裂分布(KAUFMANN,1946年)时,发现黑腹果蝇唾液X染色体的常染色质部分存在很强的相关性。这些观察结果证明了上述假设,即某些重复DNA在断裂染色体末端的DNA中提供了适当重组连接所需的同源区域。

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