黑腹果蝇体细胞中染色体畸变诱导的诱变剂特异性。
Mutagen specificity in the induction of chromosomal aberrations in somatic cells of Drosophila melanogaster.
作者信息
Pimpinelli S, Pignone D, Santini G, Gatti M, Olivieri G
出版信息
Genetics. 1977 Feb;85(2):249-57. doi: 10.1093/genetics/85.2.249.
Abstract
The distribution of chromosomal aberrations between and within chromosomes of male D, melanogaster somatic cells after treatment with UV has been analyzed. -- Distribution of the breaks between chromosomes was largely nonrandom since we found a higher aberration frequency than that expected on the Y chromosome. Moreover, within the chromosomes the aberrations are clustered in the pericentromeric heterochromatic regions. The above distribution is compared with that of the breaks induced by X rays and methyl-methane-sulphonate (MMS) which were distributed in a different pattern.
摘要
分析了经紫外线处理的雄性黑腹果蝇体细胞染色体间和染色体内染色体畸变的分布情况。——染色体间断裂的分布在很大程度上是非随机的，因为我们发现Y染色体上的畸变频率高于预期。此外，在染色体内，畸变集中在着丝粒周围的异染色质区域。将上述分布与X射线和甲基磺酸甲酯（MMS）诱导的断裂分布进行了比较，后者的分布模式不同。
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3
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