Mudò G, Bindoni M, Belluardo N
Institute of Human Physiology, Medical School, University of Catania, Italy.
Int J Neurosci. 1994 Mar;75(1-2):129-37. doi: 10.3109/00207459408986296.
The neuronal control of murine natural suppressor (NS) cell activity was studied in mice following lesion of the arcuate nucleus of the hypothalamus performed by the postnatal treatment with monosodium glutamate (MSG). The suppressor activity was evaluated as the ability of spleen or bone marrow cells (suppressors) to suppress the mitogen-induced lymphocytes proliferation of allogeneic Balb/c spleen cells (indicators). The study was carried out on three different inbred strains of mice (C57BL/6, DBA/2 and CBA). The results demonstrated that, in all strains used, the treatment of mice (12 day-old) with MSG led to a marked reduction of natural suppressor cell activity. This reduction was observed in both spleen and bone marrow, the lymphoid organs in which the NS cell activity is usually present. A reduced NS activity was also present in the bone marrow of MSG-treated adult mice, suggesting a permanent alteration of NS cell activity. These results provide additional support on neuromodulation of immune system.
通过出生后用谷氨酸钠（MSG）处理对小鼠下丘脑弓状核进行损伤，研究了小鼠天然抑制（NS）细胞活性的神经控制。抑制活性通过脾细胞或骨髓细胞（抑制细胞）抑制同种异体Balb/c脾细胞有丝分裂原诱导的淋巴细胞增殖的能力来评估（指示细胞）。该研究在三种不同的近交系小鼠（C57BL/6、DBA/2和CBA）上进行。结果表明，在所有使用的品系中，用MSG处理小鼠（12日龄）导致天然抑制细胞活性显著降低。在脾和骨髓中均观察到这种降低，NS细胞活性通常存在于这些淋巴器官中。在经MSG处理的成年小鼠的骨髓中也存在NS活性降低，表明NS细胞活性发生了永久性改变。这些结果为免疫系统的神经调节提供了额外的支持。
