Berger B, Shor P W, Tucker-Kellogg L, King J
Mathematics Department, Massachusetts Institute of Technology, Cambridge 02139.
Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7732-6. doi: 10.1073/pnas.91.16.7732.
A local rule-based theory is developed which shows that the self-assembly of icosahedral virus shells may depend on only the lower-level interactions of a protein subunit with its neighbors--i.e., on local rules rather than on larger structural building blocks. The local rule theory provides a framework for understanding the assembly of icosahedral viruses. These include both viruses that fall in the quasiequivalence theory of Caspar and Klug and the polyoma virus structure, which violates quasi-equivalence and has puzzled researchers since it was first observed. Local rules are essentially templates for energetically favorable arrangements. The tolerance margins for these rules are investigated through computer simulations. When these tolerance margins are exceeded in a particular way, the result is a "spiraling" malformation that has been observed in nature.
一种基于局部规则的理论被提出，该理论表明二十面体病毒壳的自组装可能仅取决于蛋白质亚基与其相邻亚基的低层次相互作用——即取决于局部规则而非更大的结构构建块。局部规则理论为理解二十面体病毒的组装提供了一个框架。这包括符合卡斯帕和克鲁格准等效理论的病毒，以及多瘤病毒结构，后者违反了准等效，自首次被观察以来一直困扰着研究人员。局部规则本质上是能量有利排列的模板。通过计算机模拟研究了这些规则的容差范围。当以特定方式超过这些容差范围时，结果是在自然界中观察到的“螺旋状”畸形。
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