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病毒组装、物理稳定性及动力学的理论研究

Theoretical Studies on Assembly, Physical Stability, and Dynamics of Viruses.

作者信息

Luque Antoni, Reguera David

机构信息

Department of Biology, University of Miami, Coral Gables, FL, USA.

Department of Physics of the Condensed Matter, Universitat de Barcelona, Barcelona, Spain.

出版信息

Subcell Biochem. 2024;105:693-741. doi: 10.1007/978-3-031-65187-8_19.

Abstract

All matter must obey the general laws of physics and living matter is not an exception. Viruses have not only learnt how to cope with them but have managed to use them for their own survival. In this chapter, we will review some of the exciting physics that are behind viruses and discuss simple physical models that can shed some light on different aspects of the viral life cycle and viral properties. In particular, we will focus on how the structure and shape of the viral capsid, its assembly and stability, and the entry and exit of viral particles and their genomes can be explained using fundamental physics theories.

摘要

所有物质都必须遵循物理的一般规律,生物物质也不例外。病毒不仅学会了如何应对这些规律,还设法利用它们来实现自身的生存。在本章中,我们将回顾一些病毒背后令人兴奋的物理学知识,并讨论一些简单的物理模型,这些模型可以为病毒生命周期和病毒特性的不同方面提供一些启示。特别是,我们将重点探讨如何利用基础物理理论来解释病毒衣壳的结构和形状、其组装与稳定性,以及病毒颗粒及其基因组的进出。

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