蛔虫染色质消减导致的核糖体异质性

Ribosomal heterogeneity from chromatin diminution in Ascaris lumbricoides.

作者信息

Etter A, Bernard V, Kenzelmann M, Tobler H, Müller F

机构信息

Institute of Zoology, University of Fribourg, Pérolles, Switzerland.

出版信息

Science. 1994 Aug 12;265(5174):954-6. doi: 10.1126/science.8052853.

DOI:10.1126/science.8052853

PMID:8052853

Abstract

The genome of Ascaris lumbricoides encodes both germline- and soma-specific proteins homologous to the eukaryotic small ribosomal protein (Rp) S19. The two Ascaris homologs differ by 24 amino acid substitutions and are both components of the small ribosomal subunits. In oocytes, the germline RpS19 homolog (RpS19G) predominates. During chromatin diminution, however, the gene is eliminated from all presomatic cells, and RpS19G is replaced by the product of the somatic gene (RpS19S). Chromatin diminution in A. lumbricoides causes a change in the protein composition of ribosomes during development and represents an alternative means of gene regulation.

摘要

蛔虫的基因组编码与真核小核糖体蛋白（Rp）S19同源的生殖系和体细胞特异性蛋白。这两种蛔虫同源物有24个氨基酸替换的差异，并且都是小核糖体亚基的组成部分。在卵母细胞中，生殖系RpS19同源物（RpS19G）占主导。然而，在染色质消减过程中，该基因从所有前体细胞中被消除，RpS19G被体细胞基因的产物（RpS19S）所取代。蛔虫的染色质消减在发育过程中导致核糖体蛋白质组成的变化，代表了一种基因调控的替代方式。