Etter A, Aboutanos M, Tobler H, Müller F
Institute of Zoology, University of Fribourg, Switzerland.
Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1593-6. doi: 10.1073/pnas.88.5.1593.
Chromatin diminution in the nematodes Parascaris equorum and Ascaris lumbricoides leads to the formation of somatic cells that contain less DNA than the germ-line cells. We present molecular evidence for the coding potential of germ-line-specific DNA. We report on a cDNA clone that codes for a putative ribosomal protein (ALEP-1, for A. lumbricoides eliminated protein 1). That the corresponding gene is located in the eliminated portion of the genome indicates a difference in germ-line and somatic ribosomes of A. lumbricoides and P. equorum. Elimination of the ALEP-1 gene from all somatic cells in its fully active state may represent an alternative way to gene regulation.
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