Kaptein E M, Hays M T, Ferguson D C
Department of Medicine, University of Southern California, Los Angeles.
Vet Clin North Am Small Anim Pract. 1994 May;24(3):431-66. doi: 10.1016/s0195-5616(94)50051-2.
Knowledge of thyroid hormone and iodide metabolism is derived from a combination of in vivo and in vitro studies in a variety of mammalian species including cats, dogs, and humans. Each species provides a unique opportunity to investigate various aspects of normal or altered thyroid hormone physiology. Availability of sensitive and specific human TSH assays has allowed detailed studies of the human hypothalamic-pituitary-thyroid axis which have not been possible in cats and dogs to date. Similarities and differences of thyroid hormone metabolism in dogs, cats, and humans provide the basis for a better understanding of normal physiology as well as shedding light on the significance of changes induced by spontaneous or induced thyroidal and nonthyroidal disorders.
甲状腺激素和碘代谢的知识来源于对包括猫、狗和人类在内的多种哺乳动物进行的体内和体外研究。每个物种都为研究正常或改变的甲状腺激素生理学的各个方面提供了独特的机会。灵敏且特异的人促甲状腺激素检测方法的出现，使得对人类下丘脑 - 垂体 - 甲状腺轴进行详细研究成为可能，而这在猫和狗身上至今仍无法实现。狗、猫和人类甲状腺激素代谢的异同，为更好地理解正常生理学以及揭示由自发性或诱发性甲状腺和非甲状腺疾病引起的变化的意义提供了基础。
