Detry R, Kartheuser A, Lagneaux G
Service de Chirurgie de l'Appareil digestif, Cliniques Universitaires St-Luc, Bruxelles, Belgique.
Acta Gastroenterol Belg. 1994 Mar-Apr;57(2):181-7.
Appropriate treatment of villous adenomas of the rectum remains a challenge, since accurate diagnosis can only be established after total removal of the lesion. The aim of the study was to assess the contribution of endorectal ultrasound (EUS) to diagnosis and treatment of these tumours. From 1989 to 1992, 22 patients with 24 villous adenomas of the rectum had preoperative EUS. Sixteen tumours were C1 (< 1/3 of the rectal circumference), 6 were C2 (between 1/3 and 2/3), and 2 were C3 (> 2/3). Multiple biopsies showed slight or moderate dysplasia in 12 cases, severe dysplasia or islets of invasive cancer in 12 cases. Depth of tumoural invasion could not be established. Tumours were staged by EUS as uT1 (no malignant infiltration) in 17 cases, uT2 and uT3 (invasive cancers) in 5 and 2 cases respectively. Patients had local excision of the tumours in 21 cases, and a radical rectal resection in 3. Accuracy of pathological sampling and EUS for diagnosis were evaluated, as well as the contribution of EUS to the treatment. Multiple biopsies achieved a 62% accuracy rate of diagnosis. Sensitivity in detecting invasive cancer was 71.5%. EUS reached a 92% accuracy rate; sensitivity and specificity in detecting invasive cancers were 85% and 94% respectively. The initial therapeutic option was modified in 6 patients as result of EUS stadification: undelayed surgery instead of iterative coagulations (n = 1), radical instead of local resection (n = 2) and local instead of rectal resection (n = 3).(ABSTRACT TRUNCATED AT 250 WORDS)
直肠绒毛状腺瘤的恰当治疗仍是一项挑战,因为只有在病变完全切除后才能做出准确诊断。本研究的目的是评估直肠内超声(EUS)对这些肿瘤诊断和治疗的作用。1989年至1992年,22例患有24个直肠绒毛状腺瘤的患者接受了术前EUS检查。16个肿瘤为C1期(<直肠周长的1/3),6个为C2期(介于1/3和2/3之间),2个为C3期(>2/3)。多次活检显示12例为轻度或中度发育异常,12例为重度发育异常或浸润性癌小岛。肿瘤浸润深度无法确定。EUS将肿瘤分期为uT1期(无恶性浸润)17例,uT2期和uT3期(浸润性癌)分别为5例和2例。21例患者进行了肿瘤局部切除,3例进行了根治性直肠切除术。评估了病理采样和EUS诊断的准确性以及EUS对治疗的作用。多次活检的诊断准确率为62%。检测浸润性癌的敏感性为71.5%。EUS的准确率达到92%;检测浸润性癌的敏感性和特异性分别为85%和94%。由于EUS分期,6例患者的初始治疗方案得到了修改:未延迟手术而非反复凝固(n = 1),根治性而非局部切除(n = 2),局部而非直肠切除(n = 3)。(摘要截短至250字)