Symmons D P, Barrett E M, Bankhead C R, Scott D G, Silman A J
ARC Epidemiology Research Unit, University of Manchester.
Br J Rheumatol. 1994 Aug;33(8):735-9. doi: 10.1093/rheumatology/33.8.735.
This paper provides the first data on the incidence of RA based on a prospective population-based register. All new cases of inflammatory polyarthritis in the Norwich Health Authority are notified by general practitioners to the Norfolk Arthritis Register. The patients are then clinically evaluated by metrologists and blood taken for RF estimation. Cases of RA were defined as all those notified with an onset of symptoms in 1990; who presented by 31 December 1991; and who satisfied the 1987 ARA criteria for RA at the time of presentation. Two hundred and ten patients were notified in the defined time-frame, of whom 104 were classified as having RA. The annual incidence rate was 36/100,000 for women and 14/100,000 for men. RA was rare in men aged under 45 yr. The incidence in men rose steeply with age. The incidence in women rose up to age 45 yr, plateaued to age 75 yr, and fell in the very elderly.
本文提供了基于前瞻性人群登记册得出的类风湿关节炎（RA）发病率的首批数据。诺里奇卫生局辖区内所有炎性多关节炎新病例均由全科医生上报至诺福克关节炎登记册。随后，风湿病专家对患者进行临床评估，并采集血液进行类风湿因子（RF）检测。RA病例定义为：1990年出现症状；在1991年12月31日前就诊；且就诊时符合1987年美国风湿病学会（ARA）RA标准的所有患者。在规定时间范围内共上报了210例患者，其中104例被归类为患有RA。女性的年发病率为36/10万，男性为14/10万。45岁以下男性中RA罕见。男性发病率随年龄急剧上升。女性发病率在45岁前上升，在75岁前保持平稳，在高龄时下降。
