Contreras R J, Studley J L
Florida State University, Department of Psychology, Tallahassee 32306-1051.
Chem Senses. 1994 Jun;19(3):219-29. doi: 10.1093/chemse/19.3.219.
The role of cation channels on taste cell membranes to salt taste sensation was assessed in rats. We measured the number of licks during multiple 10-s presentations of NaCl and KCl concentrations (0.05, 0.09, 0.16, 0.28, 0.5 M) dissolved in either water or in 100 microM amiloride, a sodium-channel blocker. The number of licks to water and 0.3 M sucrose was also measured. The number of licks to NaCl was significantly lower and the number of licks to KCl was significantly higher when these test solutions were dissolved in amiloride than in water. There were no differences in lick responses to water and sucrose. These results suggest that amiloride may have altered the taste of NaCl and KCl. The results are discussed in relationship to prior electrophysiological studies characterizing the effect of amiloride in blocking salt responses of the chorda tympani nerve.
在大鼠中评估了味觉细胞膜上阳离子通道对咸味觉的作用。我们测量了在多次10秒呈现溶解于水或100微摩尔氨氯吡咪（一种钠通道阻滞剂）中的氯化钠和氯化钾浓度（0.05、0.09、0.16、0.28、0.5 M）期间的舔舐次数。还测量了对水和0.3 M蔗糖的舔舐次数。当这些测试溶液溶解于氨氯吡咪中时，对氯化钠的舔舐次数显著降低，而对氯化钾的舔舐次数显著增加，与溶解于水中时相比。对水和蔗糖的舔舐反应没有差异。这些结果表明氨氯吡咪可能改变了氯化钠和氯化钾的味道。结合先前表征氨氯吡咪阻断鼓索神经盐反应作用的电生理研究对结果进行了讨论。
