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Hyperthermia-associated changes in Fos protein in the median preoptic and other hypothalamic nuclei of the pig following intravenous administration of prostaglandin E2.

作者信息

Vellucci S V, Parrott R F

机构信息

Department of Neurobiology, AFRC Babraham Institute, Cambridge, UK.

出版信息

Brain Res. 1994 May 16;646(1):165-9. doi: 10.1016/0006-8993(94)90072-8.

DOI:10.1016/0006-8993(94)90072-8
PMID:8055335
Abstract

Changes in body temperature and hypothalamic Fos production were investigated in pigs injected intravenously with prostaglandin E2 (PGE2, 20 micrograms/kg). PGE2 produced a sustained (> 150 min) hyperthermia (0.7-1 degree C) and significant increases in Fos labelling in the supraoptic and paraventricular nuclei. In addition, PGE2 induced Fos production in the median preoptic nucleus, a region previously demonstrated to be involved in thermoregulation in this species.

摘要

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