Schoenfeld T A, Clancy A N, Forbes W B, Macrides F
Worcester Foundation for Experimental Biology, Shrewsbury, MA 01545.
Brain Res Bull. 1994;34(3):183-210. doi: 10.1016/0361-9230(94)90059-0.
The spatial organization of projections from olfactory receptor neurons to the main olfactory bulb (MOB) was studied in hamsters by using fluorescent stilbene isothiocyanates as retrograde tracers. Injections confined to small sectors of the MOB produce labeling of receptor neurons that is more restricted circumferentially (i.e., with respect to the medial-lateral and dorsal-ventral axes) than longitudinally (i.e., with respect to the rostral-caudal axis) along the mucosal sheet. This restricted labeling is also discontinuous, giving an initial impression that the peripheral input is only crudely organized with respect to the medial-lateral and dorsal-ventral axes of the nasal cavity. However, from analyses of serial sections, it is apparent that each set of mucosal segments shares convergent projections to a circumferential quadrant of the MOB with other segments that are positioned around a common domain of the nasal cavity airspace. The primary afferent projections to the MOB, thus, are organized rhinotopically (i.e., with respect to the three-dimensional position of receptor neurons in olfactory space) rather than mucosotopically.
通过使用荧光芪异硫氰酸盐作为逆行示踪剂，在仓鼠中研究了嗅觉受体神经元向主嗅球（MOB）投射的空间组织。局限于MOB小区域的注射产生的受体神经元标记，沿黏膜片在圆周方向（即相对于内侧-外侧和背侧-腹侧轴）比在纵向（即相对于头端-尾端轴）更受限制。这种受限的标记也是不连续的，最初给人的印象是，外周输入在鼻腔的内侧-外侧和背侧-腹侧轴方面只是粗略地组织起来。然而，通过对连续切片的分析，很明显每组黏膜段与位于鼻腔空域共同区域周围的其他段共享向MOB圆周象限的汇聚投射。因此，向MOB的初级传入投射是按鼻腔定位组织的（即相对于嗅觉空间中受体神经元的三维位置），而不是按黏膜定位组织的。
