Sheridan J F, Dobbs C, Brown D, Zwilling B
Section of Oral Biology, Colleges of Dentistry, Ohio State University, Columbus 43210.
Clin Microbiol Rev. 1994 Apr;7(2):200-12. doi: 10.1128/CMR.7.2.200.
The mammalian response to stress involves the release of soluble products from the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis. Cells of the immune system respond to many of the hormones, neurotransmitters, and neuropeptides through specific receptors. The function of the immune system is critical in the mammalian response to infectious disease. A growing body of evidence identifies stress as a cofactor in infectious disease susceptibility and outcomes. It has been suggested that effects of stress on the immune system may mediate the relationship between stress and infectious disease. This article reviews recent psychoneuroimmunology literature exploring the effects of stress on the pathogenesis of, and immune response to, infectious disease in mammals.
哺乳动物对应激的反应涉及交感神经系统以及下丘脑 - 垂体 - 肾上腺轴释放可溶性产物。免疫系统的细胞通过特定受体对多种激素、神经递质和神经肽作出反应。免疫系统的功能在哺乳动物对传染病的反应中至关重要。越来越多的证据表明,应激是传染病易感性和疾病转归的一个辅助因素。有人提出,应激对免疫系统的影响可能介导了应激与传染病之间的关系。本文综述了近期心理神经免疫学文献,探讨应激对哺乳动物传染病发病机制及免疫反应的影响。