Rogers M P, Fozdar M
Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA.
Adv Neuroimmunol. 1996;6(2):169-77. doi: 10.1016/0960-5428(96)00015-0.
The interactions between the immune system and psychological states are both intricate and intriguing. Research at a molecular level has thrown considerable light on the previously ill-defined area of psychoneuroimmunology. In this report, we explore the psychoneuroimmunology of autoimmune disorders, particularly rheumatoid arthritis and lupus erythematosus. Animal models of these diseases have provided a particularly useful window on complex psychoneuroimmunological interactions. Observations about the effect of stress on the onset and course of autoimmune disorders has added to our understanding of psychoneuroimmunological interactions. These interactions are bi-directional, as reflected in the autoimmune-mediated neuropsychiatric manifestations of systemic lupus. Exploring the role of various neurotransmitters and neuromodulators in the stress response may have important therapeutic implications for autoimmune disorders.
免疫系统与心理状态之间的相互作用既复杂又引人入胜。分子水平的研究为之前定义不明的心理神经免疫学领域带来了诸多启示。在本报告中，我们探讨自身免疫性疾病的心理神经免疫学，尤其是类风湿性关节炎和红斑狼疮。这些疾病的动物模型为复杂的心理神经免疫学相互作用提供了一个特别有用的窗口。关于压力对自身免疫性疾病发病和病程影响的观察增进了我们对心理神经免疫学相互作用的理解。这些相互作用是双向的，如系统性红斑狼疮的自身免疫介导的神经精神表现所反映的那样。探索各种神经递质和神经调质在应激反应中的作用可能对自身免疫性疾病具有重要的治疗意义。
