放线菌素D对体外暴露于7,12-二甲基苯并(a)蒽诱导大鼠乳腺肿瘤的抑制作用。

Inhibitory effect of actinomycin D on the inductio of rat mammary tumors by in vitro exposure to 7,12-dimethylbenz(a)anthracene.

作者信息

Tominaga T, Tei N, Taguchi T, Takeda Y

出版信息

Cancer Res. 1975 Jul;35(7):1698-701.

Abstract

The inhibitory effect of actinomycin D on the induction of tumors by in vitro exposure of mammary glands to 7,12-dimethylbenz(a)anthracene was studied. When actinomycin D was given i.p. 24 hr before excision of the mammary glands, the induction of tumors by in vitro exposure of the glands to 7,12-dimethylbenz(a)anthracene was significantly decreased. On the other hand, when actinomycin D was administered 24 hr after excision, it had no effect on the induction of tumors. In vitro exposure of excised glands to 7,12-dimethylbenz(a)anthracene and actinomycin D significant decreased tumor induction. However, the order of exposure to 7,12-dimethylbenz(a)anthracene and actinomycin D influenced the inhibitory effect of actinomycin D on tumor induction. Results indicated that this might be due to a difference in the amounts of 7,12-dimethylbenz(a)anthracene and actinomycin D bound to the mammary glands.

摘要

研究了放线菌素D对体外暴露于7,12 - 二甲基苯并(a)蒽的乳腺诱导肿瘤的抑制作用。当在切除乳腺前24小时腹腔注射放线菌素D时，腺体体外暴露于7,12 - 二甲基苯并(a)蒽诱导的肿瘤明显减少。另一方面，在切除后24小时给予放线菌素D，对肿瘤诱导没有影响。切除的腺体体外暴露于7,12 - 二甲基苯并(a)蒽和放线菌素D显著降低了肿瘤诱导。然而，7,12 - 二甲基苯并(a)蒽和放线菌素D的暴露顺序影响了放线菌素D对肿瘤诱导的抑制作用。结果表明，这可能是由于与乳腺结合的7,12 - 二甲基苯并(a)蒽和放线菌素D的量不同所致。