Sinha D, Dao T L
J Natl Cancer Inst. 1975 Apr;54(4):1007-9.
Serial sections of mammary glands from female Sprague-Dawley rats were examined at different intervals after rats were treated with 7,12-dimethylbenz[a]anthracene (CMBA). DMBA was given either by intravenous (iv) injection or by local application. Lesions with histologic characteristics typical of mammary adenocarcinomas were observed in the mammary glands as early as 20 days after DMBA treatment, when no other lesions were detectable. Whereas hyperplastic alveolar nodules in the mammary glands began to appear 35 days after iv injection of DMBA, they were never observed after local application of the carcinogen. All mammary tumors were adenocarcinomas of ductal origin.
用7,12-二甲基苯并[a]蒽（DMBA）处理雌性斯普拉格-道利大鼠后，在不同时间间隔检查其乳腺的连续切片。DMBA通过静脉注射（iv）或局部应用给药。早在DMBA处理后20天，在乳腺中就观察到具有乳腺腺癌典型组织学特征的病变，此时未检测到其他病变。静脉注射DMBA后35天，乳腺中开始出现增生性肺泡结节，但局部应用致癌物后从未观察到。所有乳腺肿瘤均为导管起源的腺癌。
