Gillberg I C, Råstam M, Gillberg C
University of Göteborg, Sweden.
J Am Acad Child Adolesc Psychiatry. 1994 Jun;33(5):729-39. doi: 10.1097/00004583-199406000-00014.
Controlled study of intermediate term outcome of representative cases with adolescent-onset anorexia nervosa.
A group of 51 cases with anorexia nervosa with a mean age of reported onset of 14.3 years (including a total population of cases from one birth cohort) were compared with a sex-, age-, and school-matched group of 51 comparison subjects on various measures of outcome at a mean age of 21.0 years (6.7 years after reported onset and 4.9 years after the original diagnostic study). There was no attrition. This paper reports on results obtained using the Morgan-Russell scales.
Forty-seven percent of the anorexia nervosa cases reported that they were recovered. In the unrecovered group all aspects of outcome were worse in the anorexia nervosa than in the comparison group. Differences between the two groups were particularly pronounced with regard to aspects of social relationships.
Outcome was fairly similar to that reported in recent clinic-based samples. Poor outcome was associated with the presence of empathy deficits (problems understanding about other people's perspectives and difficulties interacting reciprocally). There is a need to find ways of subgrouping anorexia nervosa cases at onset. The subgroup with empathy deficits warrants more intensive study in future research and clinical practice.
对青少年期起病的神经性厌食症代表性病例的中期结局进行对照研究。
将一组51例神经性厌食症患者（报告的起病平均年龄为14.3岁，包括来自一个出生队列的全部病例）与一组51名对照对象进行比较，对照对象在性别、年龄和学校方面与之匹配。在平均年龄21.0岁时（报告起病后6.7年，原诊断研究后4.9年），对各项结局指标进行比较。无失访情况。本文报告使用摩根 - 拉塞尔量表获得的结果。
47%的神经性厌食症病例报告称已康复。在未康复组中，神经性厌食症患者在各个结局方面均比对照组差。两组之间在社会关系方面的差异尤为明显。
结局与近期基于临床样本报告的结果相当相似。不良结局与存在共情缺陷（难以理解他人观点及相互互动困难）有关。有必要找到在起病时对神经性厌食症病例进行亚组分类的方法。有共情缺陷的亚组在未来研究和临床实践中值得更深入研究。
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