Isonokami M, Hashimoto K, Horiguchi Y, Yoshikawa K
Department of Dermatology, Osaka University School of Medicine, Japan.
J Dermatol. 1994 Apr;21(4):268-72. doi: 10.1111/j.1346-8138.1994.tb01735.x.
We report a case of linear IgA bullous dermatosis which presented with atypical clinical and ultrastructural findings. The patient initially manifested small, subepidermal blisters scattered only in the seborrheic region. On follow-up, grouped vesicles developed in a circular form similar to dermatitis herpetiformis. They subsided after treatment with diaminodiphenyl sulphon. Immunofluorescent study showed predominant linear IgA deposits accompanied with IgG and C3 along the basement membrane zone. These deposits existed at the floor of the blister. Ultrastructurally, immunoreactants were demonstrated beneath the lamina densa while separation occurred at lamina lucida.
我们报告一例线状IgA大疱性皮肤病，其临床表现和超微结构均不典型。患者最初表现为仅散在于脂溢性区域的小的表皮下水疱。随访过程中，出现了类似疱疹样皮炎的圆形成群水疱。经二氨基二苯砜治疗后水疱消退。免疫荧光研究显示，沿基底膜带主要为线状IgA沉积，并伴有IgG和C3。这些沉积物存在于水疱底部。超微结构上，免疫反应物显示于致密板下方，而分离发生在透明板处。
