Huang Xin, Zhang You-Bo, Yang Xiu-Wei
State Key Laboratory of Natural and Biomimetic Drugs (Peking University), Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
J Asian Nat Prod Res. 2011 Oct;13(11):977-83. doi: 10.1080/10286020.2011.602015. Epub 2011 Oct 10.
Nine indoloquinazoline alkaloids (1-9) were isolated from the dried and nearly ripe fruits of Euodia rutaecarpa (Juss.) Benth. (Euodiae Fructus), along with limonin and β-sitosterol. Their structures were elucidated on the basis of their spectroscopic data. Among them, compounds 1 and 2 were new compounds and characterized as (7R,8S)-7-hydroxy-8-methoxy-rutaecarpine and (7R,8S)-7-hydroxy-8-ethoxy-rutaecarpine, respectively, and 1-hydroxy-rutaecarpine (3) and (7R,8S)-7,8-dihydroxy-rutaecarpine (4) were isolated from Euodiae Fructus for the first time. The nine indoloquinazoline alkaloids were evaluated for their cytotoxic activities against human promyelocytic leukemia HL-60 cells and human gastric carcinoma N-87 cells.
从吴茱萸（Evodia rutaecarpa (Juss.) Benth.）的干燥近成熟果实中分离出9种吲哚喹唑啉生物碱（1-9），以及柠檬苦素和β-谷甾醇。根据它们的光谱数据阐明了其结构。其中，化合物1和2为新化合物，分别鉴定为(7R,8S)-7-羟基-8-甲氧基吴茱萸碱和(7R,8S)-7-羟基-8-乙氧基吴茱萸碱，1-羟基吴茱萸碱（3）和(7R,8S)-7,8-二羟基吴茱萸碱（4）首次从吴茱萸果实中分离得到。对这9种吲哚喹唑啉生物碱针对人早幼粒细胞白血病HL-60细胞和人胃癌N-87细胞的细胞毒活性进行了评价。
