“黄银”兔：对乳酸脱氢酶同工酶LDH-H4反应高的封闭群体。控制反应的可能机制。
'Gelbsilber' rabbits: a closed colony of high responders to the lactic dehydrogenase isoenzyme LDH-H4. Possible mechanisms controlling the response.
作者信息
Falkenberg F, Frensdorff A
出版信息
Immunology. 1975 May;28(5):1001-6.
'Gelbsilber' (GS) rabbits which had been maintained for an unknown time as a closed colony, were found to respond uniformly well to the pig lactic dehydrogenase isoenzyme of the H4 type (P-LDH-H4), to which most New Zealand white (NZW) rabbits produced no detectable antibody. Two to three per cent of the splenic lymphoid cells of GS rabbits after secondary immunization were found to produce antibody to P-LDH-H4, while no such cells were detected in NZW rabbits. No differences were detected between the electrophoretic mobility of endogenous LDH of GS and NZE rabbits. The immunoglobulins of GS rabbits were heterogeneous with respect to immunoglobulin light and heavy chain allotypes. It was concluded that in GS rabbits the response to LDH-H4 is controlled by and Ir gene and that these animals might be useful in studying the genetic control of the immune response in rabbits.
作为封闭群体饲养了一段时间（时间未知）的“金黄银兔”（GS兔），被发现对H4型猪乳酸脱氢酶同工酶（P-LDH-H4）反应一致良好，而大多数新西兰白兔（NZW兔）对其不产生可检测到的抗体。二次免疫后，发现GS兔脾脏淋巴样细胞中有2%至3%产生抗P-LDH-H4抗体，而NZW兔中未检测到此类细胞。未检测到GS兔和NZE兔内源性LDH的电泳迁移率有差异。GS兔的免疫球蛋白在免疫球蛋白轻链和重链同种异型方面具有异质性。得出的结论是，在GS兔中，对LDH-H4的反应受一个免疫反应基因（Ir基因）控制，这些动物可能有助于研究兔免疫反应的遗传控制。
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