Vlasić-Matas J, Rumboldt Z, Puizina-Ivić N, Luksić B, Milas I, Dubravcić M, Forempoher G
Klinika za unutrasnje bolesti Medicinskog fakulteta u Zagrebui i Klinickog bolnickog centra u Splitu.
Lijec Vjesn. 1994 Mar-Apr;116(3-4):95-7.
An anti-HIV negative patient with cadaveric renal transplant developed Kaposi's sarcoma of the skin and gingiva 10 months after transplantation, taking triple immunosuppression (cyclosporine, azathioprine and prednisone). After reduction of the cyclosporine dose and complete cessation of azathioprine administration, the tumor regressed without rejection of renal transplant. The patient was a carrier of HLA A2 and DR5. When Kaposi's sarcoma was diagnosed serologic tests revealed reactivation of cytomegalovirus (CMV) infection. All this combined with considerable pharmacological immunosuppression, made the patient prone to develop Kaposi's sarcoma, which can regress with adequate reduction of immunosuppression.
一名接受尸体肾移植的抗HIV阴性患者,在移植后10个月,采用三联免疫抑制疗法(环孢素、硫唑嘌呤和泼尼松)时,出现了皮肤和牙龈的卡波西肉瘤。在减少环孢素剂量并完全停止使用硫唑嘌呤后,肿瘤消退,且肾移植未发生排斥反应。该患者是HLA A2和DR5携带者。诊断卡波西肉瘤时,血清学检测显示巨细胞病毒(CMV)感染复发。所有这些因素,再加上相当程度的药物免疫抑制,使患者易于发生卡波西肉瘤,而通过适当减少免疫抑制,肿瘤可以消退。