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[肾移植中应用环孢素和硫唑嘌呤治疗的卡波西肉瘤]

[Kaposi's sarcoma in kidney transplant treated with cyclosporin and azathioprine].

作者信息

Cózar J M, Martínez Piñeiro L, Avellana J A, de la Peña J, Hidalgo L, Sanz A, Burgos F, Martínez Piñeiro J A

机构信息

Servicio de Urología, Hospital La Paz. Facultad de Medicina, Universidad Autónoma Madrid, España.

出版信息

Arch Esp Urol. 1990 Mar;43(2):155-8.

PMID:2363579
Abstract

We report on a renal transplant patient who had developed Kaposi's sarcoma with cutaneous involvement 20 days after transplantation. The patient had a functioning renal graft and was on immunosuppressive therapy consisting of prednisone, azathioprine and cyclosporine. Azathioprine and cyclosporine were discontinued and chemotherapy was instituted with vinblastine first and methotrexate later; however, Kaposi's tumor did not respond to the foregoing therapeutic regimen. Thirty-two months following transplantation, the kidney graft presented acute interstitial rejection that warranted graft removal. The patient is currently receiving treatment for Kaposi's sarcoma but tumor regression has not been achieved. We discuss the atypical course of this case in comparison with those reported elsewhere.

摘要

我们报告了一名肾移植患者,该患者在移植后20天出现了伴有皮肤受累的卡波西肉瘤。患者的肾移植功能良好,正在接受由泼尼松、硫唑嘌呤和环孢素组成的免疫抑制治疗。停用了硫唑嘌呤和环孢素,并首先使用长春碱,随后使用甲氨蝶呤进行化疗;然而,卡波西肉瘤对上述治疗方案没有反应。移植后32个月,肾移植出现急性间质性排斥反应,需要切除移植肾。该患者目前正在接受卡波西肉瘤的治疗,但尚未实现肿瘤消退。我们将此病例的非典型病程与其他地方报道的病例进行了比较。

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