Heering P, Meschig R, Glück S, Kreusser W, Plewig G, Grabensee B
Abteilung für Nephrologie, Medizinische Universitätsklinik und Poliklinik, Düsseldorf.
Dtsch Med Wochenschr. 1989 Sep 15;114(37):1407-10. doi: 10.1055/s-2008-1066774.
A Kaposi's sarcoma of the skin with nodular and follicular lesions but no visceral involvement developed in a 44-year-old man nine months after transplantation of an haplo-identical kidney (a relative as donor). He was on an immunosuppressive regimen of daily 10 mg methylprednisolone and 2.5 mg/kg cyclosporin A. No HIV antibodies were demonstrated. After reduction of the dosage to 4 mg methylprednisolone and 1 mg/kg cyclosporin A no further growth of the skin lesions was observed, while transplant function was maintained. The lesions regressed after radiation of two areas in the right lower leg with 48 Gy. Ten months later the sarcoma again progressed and required further radiotherapy, which arrested growth, while there was no change in transplant function.
一名44岁男性在接受单倍体相合肾脏移植(亲属供体)九个月后,出现了皮肤卡波西肉瘤,有结节状和滤泡状病变,但无内脏受累。他正在接受每日10毫克甲泼尼龙和2.5毫克/千克环孢素A的免疫抑制方案治疗。未检测到HIV抗体。将剂量减至4毫克甲泼尼龙和1毫克/千克环孢素A后,未观察到皮肤病变进一步生长,同时移植肾功能得以维持。右小腿两个部位接受48 Gy放疗后,病变消退。十个月后,肉瘤再次进展,需要进一步放疗,放疗抑制了肿瘤生长,而移植肾功能没有变化。