Tan C T
Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur.
Med J Malaysia. 1994 Mar;49(1):68-73.
This is a study of 13 Malaysian patients with clinically definite Multiple sclerosis (MS) subjected to a hot bath test with VEPs, BAEPs, median nerve SSEPs before and after heating. Five patients (38%) developed neurological changes with the rise in body temperature. There was an average of 0.46 new sign per patient. Four patients had motor disturbances attributed mainly to aggravation of spinal cord dysfunction. Two patients had additional visual deterioration, one patient has associated VEP change. This study shows that though Uhthoff's phenomenon has not been noted in the reports of Asian MS patients, when subjected to rigorous testing, Asian MS patients also show sensitivity to body temperature change. However, the percentage of positivity of the hot bath test is much lower than that reported for Caucasians. Thus this study shows further differences between Asian and Caucasian MS patients.
这是一项针对13例临床确诊为多发性硬化症（MS）的马来西亚患者的研究，对他们进行了热水浴试验，在加热前后分别检测视觉诱发电位（VEP）、脑干听觉诱发电位（BAEP）和正中神经体感诱发电位（SSEP）。5例患者（38%）随着体温升高出现了神经学变化。平均每位患者出现0.46个新体征。4例患者出现运动障碍，主要归因于脊髓功能障碍加重。2例患者出现额外的视力恶化，1例患者伴有VEP变化。这项研究表明，尽管在亚洲MS患者的报告中未提及Uhthoff现象，但在经过严格测试时，亚洲MS患者也表现出对体温变化的敏感性。然而，热水浴试验的阳性率远低于白种人报告的阳性率。因此，这项研究进一步显示了亚洲和白种人MS患者之间的差异。
