Brenneis M, Harrer G, Selzer H
Fortschr Neurol Psychiatr Grenzgeb. 1979 Jun;47(6):320-5.
Aggravation of neurological symptoms in MS patients in heating is well known. This phenomenon is explained by the change of conduction in demyelinated nerve fibers. In raised temperature conduction block occurs. The threshold of conduction block dependent on temperature, is probably proportional to the degree of demyelination. It is possible to inhibit this effect by tyrosin. This model may present a view to a part of neurophysiological mechanisms of MS, on which we possibly can take therapeutical influence. By way of a questionnaire 125 MS patients were asked about changes of their symptoms in heating or cooling. 93% had marked sensitivity to heating. In 90% worsening of neurological symptoms or of general feeling occured in a hot bath. On the other hand about half the patients reported improvement in a cold bath. Therefore we suggest, that a noticeable part of neurological deficit is reversible, if we were able to raise the threshold of conduction block, which depends on temperature, ph, electrolytes and neurotransmitters.
多发性硬化症（MS）患者在受热时神经症状加重是众所周知的。这种现象可以用脱髓鞘神经纤维传导的变化来解释。在温度升高时会发生传导阻滞。传导阻滞的阈值取决于温度，可能与脱髓鞘程度成正比。酪氨酸可能会抑制这种效应。这个模型可能为MS的部分神经生理机制提供一种观点，我们有可能对其施加治疗影响。通过问卷调查，询问了125名MS患者在受热或受冷时症状的变化。93%的患者对受热有明显的敏感性。90%的患者在热水浴中神经症状或总体感觉会恶化。另一方面，约一半的患者报告在冷水浴中有改善。因此我们建议，如果我们能够提高取决于温度、酸碱度、电解质和神经递质的传导阻滞阈值，那么相当一部分神经功能缺损是可逆的。
