Sultanov G F, Amannepesov K, Dugin S F, Gorodetskaia E A, Agalieva L D, Medvedev O S
Patol Fiziol Eksp Ter. 1993 Mar-Apr(2):23-5.
The changes in the parameters of systemic and regional hemodynamics during thermal stress were followed up in awake male Wistar rats. The cardiac output (CO) and blood flow in 16 zones of the body were measured by means of 15 microns microspheres labeled by 4 different isotopes. The blood flow increased in the skin of the tail, the liver, heart, adrenals, and skeletal muscles and reduced in the organs of the splanchnic region and kidneys. When body temperature reached 42 degrees C the CO decreased. The shifts in the regional blood flow maintained their direction, with the exception of a sharp increase of blood flow in the small intestine which preceded or coincided with the beginning of a fall in arterial pressure. The rate of increase of left ventricular pressure remained at a high level. It is assumed that the disruption of celiac vasoconstriction is among the earlier developing links of hemodynamic disorders in thermal affections and is caused by the vasodilative effect of the factors of local control of the vascular functions.
对清醒的雄性Wistar大鼠热应激期间全身和局部血流动力学参数的变化进行了跟踪研究。通过用4种不同同位素标记的15微米微球测量了身体16个区域的心输出量（CO）和血流量。尾部皮肤、肝脏、心脏、肾上腺和骨骼肌的血流量增加，而内脏区域器官和肾脏的血流量减少。当体温达到42℃时，心输出量下降。局部血流的变化保持其方向，但小肠血流量急剧增加除外，小肠血流量增加先于或与动脉压下降开始同时发生。左心室压力的上升速率保持在较高水平。据推测，腹腔血管收缩的破坏是热损伤血流动力学紊乱早期发展环节之一，是由血管功能局部控制因素的血管舒张作用引起的。
