Seferova R I, Manenkova I D, Avetisova N L
Patol Fiziol Eksp Ter. 1993 Mar-Apr(2):25-7.
Experiments were conducted on male albino rats to study some intracellular metabolites (lactate, pyruvate, malate, glutamate, alpha-ketoglutarate, ammonia) and the redox process in the tissues of the liver, kidneys, myocardium, and skeletal muscles during hyperthermia (40 degrees C for one hour and 45 degrees C for one hour). Changes of the metabolite content and shifts in the redox process in the direction of oxidation in the liver and kidneys at both levels of hyperthermia are evidence of the development of tissue hypoxia of circulatory character in these organs. The mitochondrial NAD/NADH ratio in the myocardium reduced in moderate hyperthermia and increased during a heat stroke. There were no signs of cellular hypoxia in the skeletal muscles. It is concluded on basis of the results that changes of the blood flow in the organs play the leading role in the origin of thermal hypoxia.
以雄性白化大鼠为实验对象，研究热疗（40℃持续1小时和45℃持续1小时）期间肝脏、肾脏、心肌和骨骼肌组织中的一些细胞内代谢物（乳酸、丙酮酸、苹果酸、谷氨酸、α-酮戊二酸、氨）以及氧化还原过程。在两个热疗水平下，肝脏和肾脏中代谢物含量的变化以及氧化还原过程向氧化方向的转变，证明了这些器官中循环性组织缺氧的发展。心肌中的线粒体NAD/NADH比值在中度热疗时降低，在中暑时升高。骨骼肌中没有细胞缺氧的迹象。根据这些结果得出结论，器官中血流的变化在热缺氧的发生中起主导作用。
