Ruiz M A, Augusto L G, Vassallo J, Vigorito A C, Lorand-Metze I, Souza C A
Department of Hematology, Faculty of Medicine, State University of Campinas, UNICAMP, S. Paulo, Brazil.
Pathol Res Pract. 1994 Feb;190(2):151-4. doi: 10.1016/S0344-0338(11)80705-3.
The authors present the histological and cytological features of bone marrow (BM) in 152 employees from the steel plant of Cubatão (S. Paulo-Brazil) who presented with neutropenia, due to chronic exposure to benzene and its homologues. All patients were male. Mean age was 35 years. At the time of this study, all patients were removed from risk areas because of the hematological abnormality. BM morphology was characterized by a hypocellular hemopoiesis (82%). Decrease of the granulocytic precursors (86%) was the most outstanding feature. Erythroid and megakaryocytic series were diminished in 40% and 57% of the cases, respectively. Eosinophilia in BM was observed in 71% of the cases. Cell atypias and stromal changes (necrosis, increase in reticulin fibres) were frequent.
作者呈现了152名来自巴西圣保罗州库巴唐钢铁厂的员工骨髓的组织学和细胞学特征，这些员工因长期接触苯及其同系物而出现中性粒细胞减少症。所有患者均为男性，平均年龄35岁。在本研究进行时，由于血液学异常，所有患者均已撤离危险区域。骨髓形态学特征为造血细胞减少（82%）。粒细胞前体减少（86%）是最突出的特征。红系和巨核细胞系分别在40%和57%的病例中减少。71%的病例骨髓中观察到嗜酸性粒细胞增多。细胞异型性和基质改变（坏死、网状纤维增加）很常见。
