Babichev V N, Shishkina I V
Probl Endokrinol (Mosk). 1994 Mar-Apr;40(2):60-2.
Specificities of functioning and development of the reproductive system and mechanism of its regulation with hypothalamic structures were studied in the progeny of rats with streptozotocin diabetes. For this purpose pituitary sensitivity was analyzed in mature animals, as was functional capacity of the feedback system mediating the hypothalamic regulation of gonadotropin secretion in rat males and females at the age when this system normally starts functioning in health. The hypothalamo-hypophyseo-gonadal system feedback mechanism was found to develop in the progeny of female rats with streptozotocin diabetes later than in health. Pituitary sensitivity to LH-RH was reduced and LH level reduced by 1.5 times in mature progeny of rats with streptozotocin diabetes as compared to that in the progeny of healthy rats. These results permit a conclusion that the progeny of rats with streptozotocin diabetes develop disorders in the mechanism regulating the reproductive system of the body, though not so grave as to make this system functioning impossible.
研究了链脲佐菌素糖尿病大鼠后代生殖系统的功能和发育特异性及其与下丘脑结构的调节机制。为此，分析了成熟动物的垂体敏感性，以及在该系统正常开始发挥功能的年龄时，介导大鼠雄性和雌性促性腺激素分泌的下丘脑调节的反馈系统的功能能力。发现链脲佐菌素糖尿病雌性大鼠后代的下丘脑 - 垂体 - 性腺系统反馈机制比健康状态下发育得晚。与健康大鼠后代相比，链脲佐菌素糖尿病大鼠成熟后代的垂体对促黄体生成素释放激素（LH - RH）的敏感性降低，促黄体生成素（LH）水平降低了1.5倍。这些结果表明，链脲佐菌素糖尿病大鼠后代在调节身体生殖系统的机制中出现紊乱，尽管并不严重到使该系统无法发挥功能。
