Shtandel' S A, Artamentova L A, Tikhonova E P
Probl Endokrinol (Mosk). 1993 May-Jun;39(3):8-10.
A total of 389 patients with diabetes mellitus were examined. A genetic analysis has shown a most high possibility of diabetes in the sibs of patients with type II diabetes and secondary insulin dependence. The authors put forward a hypothesis that secondary insulin dependence formation in diabetics with type II condition results from interactions of two gene complexes with a recessive effect, responsible for types I and II diabetes mellitus development. They suggest a model of age-dependent epistasis with an 'insulin-dependence' gene quantitative effect.
共检查了389例糖尿病患者。基因分析表明，II型糖尿病和继发性胰岛素依赖患者的同胞患糖尿病的可能性极高。作者提出了一个假设，即II型糖尿病患者继发性胰岛素依赖的形成是由两种具有隐性效应的基因复合体相互作用所致，这两种基因复合体分别负责I型和II型糖尿病的发生发展。他们提出了一种具有“胰岛素依赖”基因定量效应的年龄依赖性上位性模型。
