Nottebohm F, O'Loughlin B, Gould K, Yohay K, Alvarez-Buylla A
Laboratory of Animal Behavior, Rockefeller University Field Research Center, Millbrook, NY 12545.
Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):7849-53. doi: 10.1073/pnas.91.17.7849.
The number of high vocal center (HVC) neurons labeled in adult male canaries by systemic injections of [3H]thymidine depended on season and survival time. This was true for HVC neurons projecting to the robust nucleus of the archistriatum and for other HVC neurons that could not be retrogradely filled from the robust nucleus of the archistriatum. Birds injected in October and killed 40 days later had twice as many labeled HVC neurons as birds injected in May and killed 40 days later. However, this difference became much larger (5 times) when the birds were allowed to survive for 4 months. Whereas more than half of the spring-born neurons disappeared between 40 days and 4 months, there was no reduction in the number of fall-born neurons present at the 4-month survival point. We infer that seasonal variables affect the life span of HVC neurons born in adulthood.
通过全身注射[3H]胸腺嘧啶核苷标记的成年雄性金丝雀的高发声中枢（HVC）神经元数量取决于季节和存活时间。对于投射到古纹状体粗核的HVC神经元以及无法从古纹状体粗核逆行填充的其他HVC神经元来说都是如此。10月注射并在40天后处死的鸟类，其标记的HVC神经元数量是5月注射并在40天后处死的鸟类的两倍。然而，当鸟类存活4个月时，这种差异变得更大（5倍）。虽然超过一半的春季出生神经元在40天到4个月之间消失，但在4个月存活期时秋季出生神经元的数量没有减少。我们推断，季节变量会影响成年期出生的HVC神经元的寿命。
