Garcia T M, da Costa J A, Costa R S, Ferraz A S
Renal Transplant Unit, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Ren Fail. 1994;16(3):419-23. doi: 10.3109/08860229409044882.
We report two cases of acute renal failure in renal transplant patients using cyclosporine-A (CsA) after the introduction of angiotensin-converting enzyme inhibitor (ACEI) to control arterial hypertension. They had no renal artery stenosis or acute rejection. Both patients presented severe acute tubular necrosis (ATN), which subsided after discontinuation of the ACEI. Synergistic toxic effect of ACEI and CsA on the renal tubules might explain ATN in these two cases.
我们报告了两例肾移植患者在使用环孢素A（CsA）期间引入血管紧张素转换酶抑制剂（ACEI）以控制动脉高血压后发生急性肾衰竭的病例。他们没有肾动脉狭窄或急性排斥反应。两名患者均出现严重的急性肾小管坏死（ATN），在停用ACEI后病情缓解。ACEI和CsA对肾小管的协同毒性作用可能解释了这两例患者的ATN。
