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[丙泊酚与异氟烷作为门诊手术维持麻醉剂的比较研究]

[Comparative study between propofol and isoflurane as a maintenance anesthetic in ambulatory surgery].

作者信息

Moriano E, Espinel C, Díaz-Alvarez A, Barrientos M T, Frayle E, el Busto J J

机构信息

Servicio de Anestesiología y Reanimación, Complejo Hospitalario de Salamanca, Hospital Virgen de la Vega.

出版信息

Rev Esp Anestesiol Reanim. 1994 May-Jun;41(3):172-4.

PMID:8059045
Abstract

OBJECTIVES

To evaluate postanesthetic recovery and complications in outpatient surgery for which anesthetic maintenance was achieved with either isoflurane or propofol.

PATIENTS AND METHODS

Eighty patients were randomly divided into two groups for prospective study according to anesthetic used: isoflurane (group A) or propofol (group B). The patients were undergoing short surgery and in both groups induction was with 2-2.5 mg/kg propofol, 0.4-0.5 mg/kg atracurium, 20 microgram/kg alfentanil and 20 microgram/kg droperidol. In 40 patients maintenance was with 0.5-1% isoflurane (group A) and in the remaining 40 0.1-1.15 mg/kg/min propofol (group B) was used; in both groups 50% N2O-O2 was used.

RESULTS

We found no statistically significant differences in time until eye opening after a verbal command (3.8 +/- 2 in group A and 4.1 +/- 2.8 min in group B), in time until the patient was able to answer five questions (6.5 +/- 3 in group A and 6 +/- 2.9 min in group B) or in Aldrete test scores upon awakening (9 +/- 1 in group A and 8.7 +/- 0.9 in group B). Nor were there differences in frequency of nausea reported (2 in each group) or in level of pain after surgery.

CONCLUSIONS

Recovery and incidence of complications after out-patient anesthesia were similar when anesthetic maintenance was achieved with propofol or isoflurane.

摘要

目的

评估使用异氟烷或丙泊酚进行麻醉维持的门诊手术患者的麻醉后恢复情况及并发症。

患者与方法

80例患者根据所用麻醉药物随机分为两组进行前瞻性研究:异氟烷组(A组)和丙泊酚组(B组)。患者均接受短小手术,两组诱导用药均为:2 - 2.5mg/kg丙泊酚、0.4 - 0.5mg/kg阿曲库铵、20μg/kg阿芬太尼和20μg/kg氟哌利多。40例患者用0.5 - 1%异氟烷维持麻醉(A组),其余40例用0.1 - 1.15mg/kg/min丙泊酚维持麻醉(B组);两组均使用50% N₂O - O₂。

结果

我们发现,在听到言语指令后睁眼时间(A组3.8±2分钟,B组4.1±2.8分钟)、患者能够回答5个问题的时间(A组6.5±3分钟,B组6±2.9分钟)或苏醒时的Aldrete评分(A组9±1分,B组8.7±0.9分)方面,两组之间无统计学显著差异。恶心报告频率(每组2例)或术后疼痛程度方面也无差异。

结论

使用丙泊酚或异氟烷进行麻醉维持时,门诊麻醉后的恢复情况及并发症发生率相似。

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