Kikuchi R, Kikuchi K, Hildebrandt J, Sekizawa K, Yamaya M, Sasaki H
Department of Geriatric Medicine, Tohoku University School of Medicine, Sendai, Japan.
Respir Physiol. 1994 May;96(2-3):127-37. doi: 10.1016/0034-5687(94)90121-x.
The effect of smooth muscle tone on hysteresis of collateral channels was examined and compared with that of airways, in freshly excised dog lobes. A double lumen catheter was sealed into a branch off the main bronchus, and air (Vs) flowed through the outer lumen while the pressure in the segment (Ps) was measured by the inner lumen. Collateral conductance (Gcoll) was calculated as Gcoll = Vs/Ps. In another series of experiments a pleural capsule was used to measure either segmental airway flow (Vsaw) or capsule pressure (Pcap). Segmental airway conductance (Gsaw) was calculated as Gsaw = Vsaw/(Ps-Pcap). Hysteresis for Gcoll vs lung volume (VL) curves were almost absent in control and after isoproterenol inflation Gcoll was greater than deflation Gcoll at a given VL (clockwise history). Conversely, after histamine Gcoll vs VL curves showed a counterclockwise history. The behaviors of Gcoll and Gsaw against a bronchomotor agent were similar. We conclude that major collateral channels have muscular walls, and being that of an airway type.
在新鲜切除的犬肺叶中，研究了平滑肌张力对侧支通道滞后现象的影响，并与气道的影响进行了比较。将双腔导管密封在主支气管的一个分支中，空气（Vs）通过外腔流动，而节段内压力（Ps）由内腔测量。侧支传导率（Gcoll）计算为Gcoll = Vs/Ps。在另一系列实验中，使用胸膜囊来测量节段气道流量（Vsaw）或囊内压力（Pcap）。节段气道传导率（Gsaw）计算为Gsaw = Vsaw/(Ps - Pcap)。在对照中，Gcoll与肺容积（VL）曲线的滞后现象几乎不存在，异丙肾上腺素充气后，在给定的VL下，Gcoll在充气时大于放气时的Gcoll（顺时针滞后）。相反，组胺作用后，Gcoll与VL曲线显示逆时针滞后。Gcoll和Gsaw对支气管运动剂的反应行为相似。我们得出结论，主要的侧支通道具有肌肉壁，且属于气道类型。
