[人类白细胞抗原I类和II类抗原与弥漫性毒性甲状腺肿]
[HLA class I and II antigens and diffuse toxic goiter].
作者信息
Kalinin A P, Kamynina T S, Zaretskaia Iu M, Abramov V Iu, Klinova E G, Karachintsev V I
出版信息
Ter Arkh. 1993;65(3):81-5.
The incidence rate of HLA class I and II antigens has been studied in 168 and 82 patients with diffuse toxic goiter, respectively. Positive association is found for HLA antigens A2, A3, A28, B8, B15, B17, Cw4, DR5; negative one with antigens A24, Bw4, Bw6, Cw1, Cw2, Cw3, Cw5, DR9. Prevalence of antigens B15, B17, Cw4, DR5 is associated with thyrotoxicosis severity, A2 with recurrent toxic goiter. Antigen B8 plays the role of an immunogenetic marker of endocrine ophthalmopathy.
分别对168例弥漫性毒性甲状腺肿患者和82例患者进行了HLA I类和II类抗原发生率的研究。发现HLA抗原A2、A3、A28、B8、B15、B17、Cw4、DR5呈正相关；与抗原A24、Bw4、Bw6、Cw1、Cw2、Cw3、Cw5、DR9呈负相关。抗原B15、B17、Cw4、DR5的流行率与甲状腺毒症严重程度相关，A2与复发性毒性甲状腺肿相关。抗原B8在内分泌性眼病中起免疫遗传标记物的作用。
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