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[脉冲式低氧血症在阻塞性肺疾病治疗中的应用]

[Pulsed hypoxia in the treatment of obstructive lung diseases].

作者信息

Sil'vestrov V P, Kovalenko E A, Krysin Iu S

出版信息

Ter Arkh. 1993;65(3):9-12.

PMID:8059397
Abstract

A new approach to the treatment of chronic nonspecific pulmonary diseases is proposed: helium-oxygen therapy combined with repeated interrupted hypoxic stimuli. Helium inclusion into hypoxic gas mixture leads to reduced air density. Gas mixture containing 10-15% of oxygen is more effective at the level of alveolocapillary membrane. When conducted in normal atmospheric pressure, the method involved no complications and produced positive responses in coronary heart disease, hypertension, alimentary diseases. The mixture of helium with oxygen (85-90% of helium, 10-15% oxygen) in combination with impulse normobaric hypoxia has been tried in 25 chronics with obstructive bronchitis and bronchial asthma. The results were indicative of the treatment efficacy: bronchial permeability improved in 67% of the cases, forced vital capacity of the lungs increased, inspiratory reserve volume grew, dyspnea and cough diminished, sputum discharge improved, general tonicity and performance status changed positively. Six-month follow-up evidenced positive shifts too.

摘要

提出了一种治疗慢性非特异性肺部疾病的新方法

氦氧疗法结合反复间歇性低氧刺激。将氦气加入低氧混合气体中会导致空气密度降低。含10 - 15%氧气的混合气体在肺泡毛细血管膜水平更有效。在正常大气压下进行该方法时,无并发症发生,且对冠心病、高血压、消化系统疾病产生了积极反应。氦氧混合气体(氦气占85 - 90%,氧气占10 - 15%)结合脉冲常压低氧已在25例慢性阻塞性支气管炎和支气管哮喘患者中进行了试验。结果表明该治疗方法有效:67%的病例支气管通透性改善,肺用力肺活量增加,吸气储备量增大,呼吸困难和咳嗽减轻,痰液排出改善,全身张力和身体状况呈积极变化。六个月的随访也证明了积极的变化。

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1
[Pulsed hypoxia in the treatment of obstructive lung diseases].[脉冲式低氧血症在阻塞性肺疾病治疗中的应用]
Ter Arkh. 1993;65(3):9-12.
2
Beneficial effects of helium:oxygen versus air:oxygen noninvasive pressure support in patients with decompensated chronic obstructive pulmonary disease.氦氧混合气体与空气氧混合气体无创压力支持对失代偿期慢性阻塞性肺疾病患者的有益作用。
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[Results of utilization of intermittent normobaric hypoxia in patients with bronchial asthma and chronic obstructive bronchitis].
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The effect of helium and oxygen on exercise performance in chronic obstructive pulmonary disease: a randomized crossover trial.氦气和氧气对慢性阻塞性肺疾病运动能力的影响:一项随机交叉试验。
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