Lukin E P, Chernikova N K
Vopr Virusol. 1993 Mar-Apr;38(2):71-4.
Serological studies on the levels of virus-neutralizing antibodies (VNA) against Venezuelan equine encephalomyelitis virus (VEE) were carried out by the standard method in 280 human subjects given a single primary inoculation of experimental forms of live vaccines against VEE prepared from attenuated strains No. 15 and No. 230. The VNA were found to persist in the blood of the vaccinees for 5-25 years (the observation period) from the time of vaccination practically at the same level. The VNA titres did not depend on the form of the preparation (for subcutaneous or oral administration) used for immunization. Similar studies were carried out on sera from 17 convalescents after VEE experienced in the past. An identical result was obtained. It is suggested that immunity to VEE persists for life.
采用标准方法，对280名单次接种由15号和230号减毒株制备的委内瑞拉马脑炎（VEE）实验性活疫苗的人体受试者，进行了针对VEE病毒中和抗体（VNA）水平的血清学研究。从接种疫苗之时起，在长达5 - 25年（观察期）的时间里，疫苗接种者血液中的VNA实际上维持在相同水平。VNA滴度并不取决于用于免疫的制剂形式（皮下或口服给药）。对17名既往患过VEE的康复者的血清进行了类似研究，得到了相同结果。这表明对VEE的免疫力可终生持续。
