Roldán Martín M B, Suárez Cortina L, Perdomo Giraldi M, Camarero Salces C, Escobar Castro H
Unidad de Gastroenterología, Hospital Ramón y Cajal, Facultad de Medicina, Universidad de Alcalá de Henares.
Acta Gastroenterol Latinoam. 1994;24(1):37-40.
Intestinal permeability was studied in a group of 10 children diagnosed of coeliac disease either when they presented an intestinal villi atrophy while receiving a gluten-containing diet and after, when they had a normal mucosa with the withdrawal of gluten from the diet. Ten healthy children served as controls. The 51 Cr-EDTA (51 Cr-ethylenediaminetetraacetate) was used as probe molecule and it was administered orally. Its urinary excretion showed clear differences between patients with an altered intestinal biopsy and those with a normal histopathology. The excretion of 51 Cr-EDTA remained elevated in celiac patients with a gluten-free diet and normal villi.
对一组10名被诊断患有乳糜泻的儿童进行了肠道通透性研究，这些儿童在摄入含麸质饮食时出现肠道绒毛萎缩，之后在饮食中去除麸质且黏膜正常时再次进行研究。10名健康儿童作为对照。使用51 Cr-乙二胺四乙酸（51 Cr-EDTA）作为探针分子并口服给药。肠道活检结果异常的患者与组织病理学正常的患者相比，其尿液排泄情况存在明显差异。在采用无麸质饮食且绒毛正常的乳糜泻患者中，51 Cr-EDTA的排泄量仍然较高。
