Doi-Yi R, Kitamoto T, Ogomori K, Mehraein P, Tateishi J
Department of Neuropsychiatry, Kumamoto University Medical School, Japan.
Acta Neuropathol. 1994;87(5):481-3. doi: 10.1007/BF00294174.
We investigated the distribution of prion protein (PrP) in 14 German patients with sporadic Creutzfeldt-Jakob disease (CJD) and compared it with that observed in Japanese patients. Immunohistochemical study revealed diffuse gray matter stainings including synaptic structures in all cases. In addition, 4 patients showed plaque-type deposition which was very rarely observed among sporadic Japanese patients without known mutation of the PrP gene but with valine at codon 129. A higher incidence of PrP plaques in German sporadic CJD may be related to the racial difference in the PrP gene.
我们研究了14例德国散发性克雅氏病（CJD）患者中朊病毒蛋白（PrP）的分布情况，并将其与日本患者的情况进行了比较。免疫组织化学研究显示，所有病例的灰质均呈弥漫性染色，包括突触结构。此外，4例患者出现斑块样沉积，在日本散发性患者中，这种情况在PrP基因无已知突变但密码子129处为缬氨酸的患者中很少见。德国散发性CJD中PrP斑块的发生率较高可能与PrP基因的种族差异有关。
