Wingfield M, O'Herlihy C, Finn M M, Tallon D F, Fottrell P F
Department of Obstetrics and Gynaecology, University College Dublin, Ireland.
Gynecol Endocrinol. 1994 Mar;8(1):21-5. doi: 10.3109/09513599409028453.
Twenty-three women with laparoscopically diagnosed early-stage endometriosis collected daily saliva samples at home and brought them to the laboratory at the completion of each menstrual cycle. Levels of progesterone in the saliva were determined by enzymeimmunoassay. Samples were collected for three cycles by one patient, for two cycles by 15 patients and for one cycle be seven women, resulting in a total of 40 cycles for analysis. Only 20 (50%) cycles were classified as normal. In 18 cycles (45%) progesterone levels exceeded the 95th percentile of the normal range. These high levels occurred in the follicular phase only in seven (18%) cycles, in the luteal phase only in eight (20%) and in both follicular and luteal phases in three (7.5%) cycles. Three cycles were anovulatory. One of these cycles also demonstrated elevated progesterone levels in the follicular phase and is therefore included in the 18 cycles mentioned above. We conclude that ovarian function is altered in a significant number of infertile women with endometriosis. However, these alterations are often subtle and only detected by detailed investigation.
23名经腹腔镜诊断为早期子宫内膜异位症的女性在家中每日采集唾液样本，并在每个月经周期结束时将样本带到实验室。通过酶免疫测定法测定唾液中的孕酮水平。1名患者采集了3个周期的样本，15名患者采集了2个周期的样本，7名女性采集了1个周期的样本，总共40个周期可供分析。只有20个（50%）周期被归类为正常。在18个周期（45%）中，孕酮水平超过了正常范围的第95百分位数。这些高水平仅在7个（18%）周期的卵泡期出现，仅在8个（20%）周期的黄体期出现，在3个（7.5%）周期的卵泡期和黄体期均出现。3个周期无排卵。其中1个周期在卵泡期也显示孕酮水平升高，因此包含在上述18个周期中。我们得出结论，大量患有子宫内膜异位症的不孕女性的卵巢功能发生了改变。然而，这些改变往往很细微，只有通过详细调查才能检测到。
