Cerhan J R, Folsom A R, Potter J D, Prineas R J
Division of Epidemiology, University of Minnesota School of Public Health, Minneapolis 55454.
Am J Epidemiol. 1994 Aug 15;140(4):368-74. doi: 10.1093/oxfordjournals.aje.a117259.
Left-handedness has been associated with decreased longevity, although this finding is controversial and not universal. The authors prospectively studied 39,691 women aged 55-69 years from the Iowa Women's Health Study through 5 years of mortality follow-up. No increase in mortality risk was found for left-handed women as compared with right-handed women (age-adjusted hazard ratio 1.10, 95% confidence interval (CI) 0.86-1.39) or for ambidextrous women (age-adjusted hazard ratio 1.05, 95% CI 0.73-1.49). Adjustment for body mass index, body fat distribution, smoking, and education did not alter these findings. Further analysis by cause-specific mortality (breast cancer, all other cancer, and circulatory disease) showed no relation to handedness. There was no difference in the mean age at death of left-handed, right-handed, and ambidextrous women. These findings do not support an association between left-handedness and increased mortality risk.
左利手与寿命缩短有关，尽管这一发现存在争议且并非普遍现象。作者对爱荷华州女性健康研究中39691名年龄在55至69岁之间的女性进行了前瞻性研究，随访5年观察死亡率。与右利手女性相比，左利手女性未发现死亡风险增加（年龄调整后的风险比为1.10，95%置信区间[CI]为0.86 - 1.39），双手灵活的女性也未发现死亡风险增加（年龄调整后的风险比为1.05，95%CI为0.73 - 1.49）。对体重指数、体脂分布、吸烟和教育程度进行调整后，这些结果并未改变。按特定病因死亡率（乳腺癌、所有其他癌症和循环系统疾病）进行的进一步分析显示，与利手无关。左利手、右利手和双手灵活的女性的平均死亡年龄没有差异。这些发现不支持左利手与死亡风险增加之间存在关联。
