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A型肉毒杆菌毒素用于治疗面部痉挛。

The use of botulinum toxin type A for the treatment of facial spasm.

作者信息

Serrano L A

机构信息

Department of Ophthalmology University of Puerto Rico School of Medicine.

出版信息

Bol Asoc Med P R. 1993 Jan-Mar;85(1-3):7-11.

PMID:8060446
Abstract

We describe our experience with the use of botulinum A toxin for the treatment of patients with facial spasms. Thirty four patients with blepharospasm, thirty eight with hemifacial spasms and three with spastic entropion were injected with the use of Botulinum A toxin. Length of follow up ranged from 6 to 60 months. The effect of toxin lasted an average of 12.1 weeks in patients with blepharospasm and 15.5 weeks in patients with hemifacial spasms. This difference in mean response was statistically significant (p = 0.0001). The most common side effect was ptosis and dry eyes. All side effects were transient in nature, lasting between three and twelve weeks. Botulinum toxin type A injections represent a good alternative for the treatment of facial spasms. It is a safe and effective office procedure. Most patients tolerate the procedure well. Its principal drawback is its transient effect and the need for repeated injections.

摘要

我们描述了使用A型肉毒杆菌毒素治疗面部痉挛患者的经验。34例眼睑痉挛患者、38例半面痉挛患者和3例痉挛性睑内翻患者接受了A型肉毒杆菌毒素注射。随访时间为6至60个月。毒素对眼睑痉挛患者的作用平均持续12.1周,对半面痉挛患者平均持续15.5周。这种平均反应的差异具有统计学意义(p = 0.0001)。最常见的副作用是上睑下垂和干眼。所有副作用都是暂时的,持续3至12周。A型肉毒杆菌毒素注射是治疗面部痉挛的一种良好替代方法。这是一种安全有效的门诊治疗。大多数患者对该治疗耐受性良好。其主要缺点是效果短暂,需要重复注射。

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