Ryder R W, Nsuami M, Nsa W, Kamenga M, Badi N, Utshudi M, Heyward W L
Project SIDA, Kinshasa, Zaïre.
AIDS. 1994 May;8(5):667-72. doi: 10.1097/00002030-199405000-00014.
To calculate 3-year mortality rates in HIV-1-seropositive and HIV-1-seronegative mothers, their newborn children and the fathers of these children.
Longitudinal cohort study of HIV-1-seropositive, age and parity-matched HIV-1-seronegative pregnant women, their newborn babies and the fathers of these children.
Obstetric ward and follow-up clinic at a large municipal hospital in Kinshasa, Zaïre.
A total of 335 newborn children and their 327 HIV-1-seropositive mothers and 341 newborn children and their 337 HIV-1-seronegative mothers and the fathers of these children.
Rates of vertical HIV-1 transmission and maternal, paternal and early childhood mortality.
The lower and upper bounds of vertical transmission were 27 and 50%, respectively. The 3-year mortality rate was 44% in children with vertically acquired HIV-1 infection, 25% in children with HIV-1-seropositive mothers and indeterminant HIV-1 infection status, and 6% in uninfected children with HIV-1-seronegative mothers. HIV-1-seropositive women who transmitted HIV-1 infection to their most recently born child had lost a greater number of previously born children (mean, 1.5 versus 0.5; P < 0.05), were more likely to have had AIDS at delivery (25 versus 12%; P < 0.01) and were more likely to die during follow-up (22 versus 9%; P < 0.01) than HIV-1-seropositive women who did not transmit HIV-1 infection to their newborn child. Twenty-five out of 239 (10.4%) fathers of children with HIV-1-seropositive mothers, not lost to follow-up, died compared with three out of 310 (1%) fathers of children with HIV-1-seronegative mothers (P < 0.01).
Families in Kinshasa, Zaïre, in which the mother was HIV-1-seropositive experienced a five to 10-fold higher maternal, paternal and early childhood mortality rate than families in which the mother was HIV-1-seronegative.
计算HIV-1血清阳性和HIV-1血清阴性母亲、她们的新生儿以及这些孩子的父亲的3年死亡率。
对HIV-1血清阳性、年龄和胎次匹配的HIV-1血清阴性孕妇、她们的新生儿以及这些孩子的父亲进行纵向队列研究。
扎伊尔金沙萨一家大型市立医院的产科病房和随访诊所。
共335名新生儿及其327名HIV-1血清阳性母亲，以及341名新生儿及其337名HIV-1血清阴性母亲和这些孩子的父亲。
HIV-1垂直传播率以及母亲、父亲和儿童早期死亡率。
垂直传播的下限和上限分别为27%和50%。在垂直感染HIV-1的儿童中，3年死亡率为44%；在母亲HIV-1血清阳性但感染状况不确定的儿童中，死亡率为25%；在母亲HIV-1血清阴性的未感染儿童中，死亡率为6%。将HIV-1感染传播给其最近出生孩子的HIV-1血清阳性女性，与未将HIV-1感染传播给其新生儿的HIV-1血清阳性女性相比，失去的先前出生孩子数量更多（平均为1.5个对0.5个；P<0.05），分娩时患艾滋病的可能性更大（25%对12%；P<0.01），随访期间死亡的可能性也更大（22%对9%；P<0.01）。在239名母亲HIV-1血清阳性且未失访的孩子的父亲中，有25人（10.4%）死亡，而在310名母亲HIV-1血清阴性的孩子的父亲中，有3人（1%）死亡（P<0.01）。
在扎伊尔金沙萨，母亲为HIV-1血清阳性的家庭，其母亲、父亲和儿童早期死亡率比母亲为HIV-1血清阴性的家庭高5至10倍。
