Bo P, Marchioni E, Soragna D, Savoldi F
Istituto Neurologico C. Mondino, Università di Pavia.
Boll Soc Ital Biol Sper. 1993 Nov;69(11):705-10.
This study aimed to investigate the effects of monosialoganglioside (GM1) when administered early in a model of cerebral focal ischemia, in the rabbit. The statistical evaluation of the electroencephalographic changes (quantified EEG analysis, QEEG) due to the ischemic event showed that the early treatment (1-3-24 h) with GM1 reduced the EEgraphic pattern typical of this model of cerebral ischemia. Considering the observation period, we hypothesized that it was due to the formation of an oedema of a lesser degree compared to the untreated group. Particularly, we did not obtain the increase in delta activity on the contralateral hemisphere, which we thought was expression of the diaschisi phenomenon.
本研究旨在探讨单唾液酸神经节苷脂（GM1）在兔局灶性脑缺血模型中早期给药的效果。对缺血事件引起的脑电图变化（定量脑电图分析，QEEG）进行的统计学评估表明，GM1早期治疗（1 - 3 - 24小时）减少了该脑缺血模型典型的脑电图模式。考虑到观察期，我们推测这是由于与未治疗组相比形成了程度较轻的水肿。特别是，我们未观察到对侧半球δ活动增加，我们认为这是失联络现象的表现。
