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用多氯联苯混合物1242诱导鸡胚染色体断裂的尝试。

Attmepts to induce chromosomal breakage in chicken embryos with Aroclor 1242.

作者信息

Blazak W F, Marcum J B

出版信息

Poult Sci. 1975 Jan;54(1):310-2. doi: 10.3382/ps.0540310.

DOI:10.3382/ps.0540310
PMID:806068
Abstract

Fertile White Leghorn eggs were injected with Aroclor 1242 and incubated for four to five days. More than 65 percent of the exposed embryos died prior to examination at the end of the incubation period. The five largest pairs of chromosomes from allantoic squashes were examined for the presence of chromosomal breakage in 753 metaphases from PCB-treated eggs and 196 metaphases from controls. Failure to detect chromosomal aberrations in either group indicated that Aroclor 1242, in concentrations of 10 p.p.m. or 20 p.p.m. in the egg, is not an effective clastogen in the chicken embryo.

摘要

将可育的白来航鸡鸡蛋注射Aroclor 1242,然后孵化四到五天。超过65%的受暴露胚胎在孵化期结束检查前死亡。对来自尿囊压片的五对最大染色体进行检查,以检测753个来自多氯联苯处理鸡蛋的中期分裂相和196个来自对照的中期分裂相中是否存在染色体断裂。两组均未检测到染色体畸变,这表明鸡蛋中浓度为10 ppm或20 ppm的Aroclor 1242在鸡胚胎中不是一种有效的致断裂剂。

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