Lockhart S P
Lederle Laboratories, Gosport.
Br J Clin Pract Suppl. 1994 May-Jun;75:48-55; discussion 56-7.
Lansoprazole is an inhibitor of gastric H+,K(+)-ATPase, commonly referred to as the 'proton pump'. The pharmacodynamic effect of proton pump inhibition is to reduce gastric acid secretion. Long experience with H2 antagonists and more recently proton pump inhibitors has demonstrated the value of reducing gastric acid secretion in conditions where acid plays a key role in the pathogenesis of gastrointestinal inflammation and ulceration. The pharmacokinetics, pharmacodynamics and clinical safety of lansoprazole are discussed elsewhere in this supplement, and so this review will focus upon the European and American experience of the efficacy of lansoprazole in the treatment of peptic ulceration and gastro-oesophageal reflux.
兰索拉唑是一种胃H⁺，K⁺-ATP酶抑制剂，通常被称为“质子泵”。抑制质子泵的药效学作用是减少胃酸分泌。使用H2拮抗剂以及最近使用质子泵抑制剂的长期经验已证明，在胃酸在胃肠道炎症和溃疡发病机制中起关键作用的情况下，减少胃酸分泌具有重要价值。兰索拉唑的药代动力学、药效学和临床安全性在本增刊的其他地方进行了讨论，因此本综述将重点关注欧美地区使用兰索拉唑治疗消化性溃疡和胃食管反流的疗效经验。
