Akpom C A, Warren K S
Am J Pathol. 1975 Jun;79(3):435-52.
The effect of protein, calorie, and vitamin deficiency states on the granulomatous response of mice to eggs of S mansoni injected into the microvasculature of the lungs was studied. Moderate to severe protein and calorie deficiencies, as well as thiamine and vitamin C deficiencies, inhibited the host's granulomatous response to S mansoni eggs, which is a form of delayed-type hypersensitivity. The antivitamins neopyrithiamine hydrochloride and desoxypyridoxine hydrochloride were both highly effective in suppressing granuloma formation, but the former proved highly toxic at the doses utilized. Desoxypyridoxine hydrochloride given at a dose of .05 mg/mouse/day produced almost complete inhibition of granuloma formation; marked suppression was also present at fivefold dilution. This antivitamin appearts to be one of the most powerful immunosuppressive measures so far examined.
研究了蛋白质、热量和维生素缺乏状态对小鼠肺部微血管注射曼氏血吸虫卵后肉芽肿反应的影响。中度至重度蛋白质和热量缺乏，以及硫胺素和维生素C缺乏，均抑制宿主对曼氏血吸虫卵的肉芽肿反应，这是一种迟发型超敏反应形式。抗维生素盐酸新吡硫胺和盐酸脱氧吡哆醇在抑制肉芽肿形成方面均非常有效，但前者在所使用的剂量下毒性极高。以0.05毫克/小鼠/天的剂量给予盐酸脱氧吡哆醇几乎完全抑制了肉芽肿形成；在五倍稀释时也有明显的抑制作用。这种抗维生素似乎是迄今为止所研究的最强大的免疫抑制措施之一。
