Wong C O, Meyerrose G E, Sostre S
Johns Hopkins Medical Institutions, Division of Nuclear Medicine, Baltimore, MD 21287.
Eur J Nucl Med. 1994 May;21(5):445-8. doi: 10.1007/BF00171421.
Cerebral atrophy often coexists with other brain disorders and by itself may alter the pattern of cerebral perfusion. If unrecognized, it may confound diagnoses based on brain single-photon emission tomography (SPET). In this retrospective study, we describe and evaluate criteria for the diagnosis of cerebral atrophy on technetium-99m hexamethylpropylene amine oxime brain SPET studies. The SPET scans of 11 patients with cerebral atrophy and ten controls were evaluated for the presence of a prominent interhemispheric fissure, presence of prominent cerebral sulci, separation of thalamic nuclei, and pronounced separation of caudate nuclei. The SPET studies were interpreted by two independent observers blind to the findings of magnetic resonance imaging, which provided the final diagnosis of cerebral atrophy. The combination of the four scintigraphic signs was accurate in the diagnosis of cerebral atrophy in 95% of the cases and had a sensitivity of 91% and a specificity of 100%.
脑萎缩常与其他脑部疾病并存，其本身可能会改变脑灌注模式。如果未被识别，它可能会混淆基于脑单光子发射断层扫描（SPET）的诊断。在这项回顾性研究中，我们描述并评估了在锝-99m六甲基丙烯胺肟脑SPET研究中诊断脑萎缩的标准。对11例脑萎缩患者和10例对照的SPET扫描进行评估，观察是否存在明显的半球间裂、明显的脑沟、丘脑核分离以及尾状核明显分离。由两名对磁共振成像结果不知情的独立观察者对SPET研究进行解读，磁共振成像提供了脑萎缩的最终诊断。这四种闪烁显像征象的组合在95%的病例中对脑萎缩的诊断是准确的，敏感性为91%，特异性为100%。
